The backstory: GLP-1s, a class of drugs that include semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound), were initially prescribed to treat Type 2 diabetes, but have soared in popularity because of weight loss
However, many liver specialists and pharmacists prefer a safety buffer of 3,000mg per day, especially if you are taking it for several days in a row
[DOI] [PubMed] [Google Scholar] Mannucci E, Tesi F, Bardini G, Ognibene A, Petracca MG, Ciani S, Pezzatini A, Brogi M, Dicembrini I, Cremasco F, et al
ASCPs guidance provides ten statements focused on avoiding DDIs and prescribing cascades and encouraged medication reviews to mitigate potential ADEs 25 : DO NOT initiate medications to treat new and emerging symptoms without first ascertaining that the new symptom is not an ADE related to an already prescribed medication
It is a consequence of weight loss, not a direct pharmacological side effect of Ozempic