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In the following part, we will describe the different vaccine-based strategies of senotherapeutics that have been studied, and we will show the limitations of some of them to be used into clinics

doi: 10.1080/17512433.2019.1552135

It is clinical suitability, safety and long-term outcomes

For example, neurexin-1 and LRRTM4 bind in a Ca 2+ -dependent manner [61], which may suggest that synaptic adhesion molecules can sense synaptic activity (Ca 2+ release) and thereby cause a change in protein structure to form a protein conformation for binding by both pre- and postsynaptic adhesion molecules, leading to the formation of transsynaptic adhesion molecules

doi: 10.1155/2021/7316456