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The divergence in the effect of mutagenesis of residues comprising the TM-binding pocket, even where interactions in the static consensus structures were similar, confirmed that static visualisation of complexes is insufficient to fully understand binding and activation mechanisms, and suggests that the dynamics of peptide-receptor engagement likely play a critical role

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Such futuristic therapeutics have been found to improve cardiovascular, renal, and metabolic disorders and can be used in patients who have issues besides diabetes and obesity

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