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PD models consistently reveal disrupted iron homeostasis, characterized by upregulation of divalent metal transporter 1 (DMT1) and downregulation of ferroportin 1, thereby promoting excessive cellular iron accumulation (Zhang et al., 2021)
G., & Smith, P
Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism
10.1007/s10534-018-0150-2 BioMetals
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