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The levels of HIF-1 and HO-1 were raised in diabetic kidney tissue exacerbated tubular iron accumulation, enhanced the lipid peroxidation response, and augmented the generation of ROS

Subsequently, this results in an imbalance of mitochondrial activity, ultimately facilitating synaptic malfunction [75]

The cellular effects of glucosylceramide, although similar to ceramides themselves, does exhibit cell-type specificity

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10.1111/pedi.13148 [DOI] [PMC free article] [PubMed] [Google Scholar] Mizgier M., Jarzabek-Bielecka G., Formanowicz D., Jodlowska-Siewert E., Mruczyk K., Cisek-Wozniak A., et al