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The FDA acknowledges BII and has worked to increase awareness

Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

Adjunct Therapy : Used alongside standard treatments for NSAID-induced ulcers or inflammatory gut conditions to enhance recovery and protect the gut lining

Together they cover gut lining repair, inflammation control and immune defence at the gut level