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However, due to technical limitations in measuring glucagon secretion in zebrafish 16 , we were unable to determine whether GCGR deficiency increases glucagon secretion at the single-cell level

This can result in rapid-onset hyperkalemia, malignant arrhythmias, and sudden cardiac arrest , sometimes in children with previously undiagnosed muscular dystrophy (Bohringer et al., 2019

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A landmark review by Pickart and Margolina in Biomolecules confirming GHK-Cus broad gene regulatory influence on tissue repair pathways supports its complementary role alongside metabolic interventions like NAD+ therapy