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Of course this got me curious

The drugs have exploded in popularity, leading to today's global shortage

1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies

n=141 ALC, n=139 control), the pooled estimate also favored ALC, though the confidence interval included the possibility of no effect (SMD 1.33, 95% CI 2.80 to 0.14