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Other common gastrointestinal adverse effects include constipation, vomiting (59% in diabetes trials, higher in obesity trials), diarrhea (1316%), decreased appetite (59%), and abdominal discomfort

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If youre trying to understand the difference between semaglutide and tirzepatide, the short answer is this: they work in similar ways, but tirzepatide activates an additional metabolic pathway, which often leads to greater weight loss for some people

In practical terms, this means retatrutide users burn more calories at rest than tirzepatide users at equivalent appetite suppression levels

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