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Insulin inhibits lipolysis (breakdown of stored fat) by inhibiting hormone-sensitive lipase (HSL) and stimulates uptake of fats into adipose tissue which traps them there, making us fat
However, chronic ethanol consumption inhibits AMPK activity by blocking the phosphorylation of enzymes essential for lipid metabolism, such as acetyl-CoA carboxylase (ACC) and CPT-1, resulting in reduced fatty acid oxidation (Hwang et al., 2025)
It sounds simple, but our team has seen firsthand how this one procedure can make or break a study
doi: 10.1111/j.1439-0531.2006.00799.x
International journal of geriatric psychiatry
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