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In patients with DM2 the incretin response is diminished, but the insulinotropic effect of GLP-1 is conserved.28 Under normal conditions GLP-1 has a short half-life (approximately 2 min), as it is rapidly degraded by dipeptidylpeptidase 4, so GLP-1 analogues resistant to this enzyme have been developed for the treatment of DM2.29 arGLP-1: glucagon-like peptide 1 receptor agonist

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Weight regain after bariatric surgery affects many patients within 25 years post-operatively, prompting growing interest in pharmacologic interventions

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But the GLP-1 telehealth landscape is complicated, and the gap between marketing promises and reality can be uncomfortably wide