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Additionally, adaptive thermogenesis slows metabolism beyond what body composition changes predict

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Lancet 359:20532058 Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, Norgren L, Van Belle E, Committees T, Investigators (2011) Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia

However, exceeding recommended therapeutic doses increases the risk of adverse effects, particularly severe nausea, vomiting, and dehydration