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In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

During successful weight loss, muscle volume may decline while muscle composition, relative strength, insulin sensitivity, and movement efficiency improve

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Sustained weight loss with combined LEAP2 and semaglutide treatment in mice

Your weight is "normal." Yet your belly won't budge, your blood sugar is creeping up, and your doctor says everything looks fine on paper