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The blocking of neurotransmitters' transportation to their vesicles increases their concentration in the cytosol and this in turn exposes them to oxidative deamination by monoamine oxidase (MAO), the enzyme found in the mitochondrial outer membrane

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This study demonstrates that a three-month treatment with methylcobalamin and folinic acid is associated with significant improvements in behavioral symptoms associated with autism spectrum disorder in a group of children with autistic disorder and metabolic markers of abnormal redox and methylation metabolism

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