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10.1113/JP272857 19 BurgerH

Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg for 4 weeks, then increased in 2.5 mg increments to a target dose of 5-15 mg based on glycemic control and tolerability

Others, such as Exubera (inhaled insulin) failed due to poor market penetration as well as safety concerns associated with drug accumulation in the lungs [217, 218]

CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects