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Indeed, direct tests revealed a lack of input specificity of synaptic changes in CA1 inhibitory neurons (McMahon and Kauer, Thus, initial studies demonstrate that CA1 interneurons can express long-term synaptic plasticity, which is calcium-dependent (Cowan et al., 2+ imaging has demonstrated that synaptically induced rises of [Ca 2+ ] i in aspiny dendrites do not spread much but are kept local by interneuron-specific mechanisms (Goldberg et al., Box 1 and below in the sections on calcium signals and heterosynaptic plasticity

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Complementary mechanisms, pressure control plus neuronal protection potentially superior to either alone

Talk to your healthcare provider and see the detailed Instructions for Use that comes with DUPIXENT for information on how to prepare and inject DUPIXENT and how to properly store and throw away (dispose of) used DUPIXENT Pre-filled Syringes or DUPIXENT Pre-filled Pens prior to taking the drug