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If nausea is intolerable, the dose of the current agent may be reduced (if possible) or another class of GLP-1RA may be trialled

GHK-Cu modulates the expression of a large number of human genes studies using gene expression microarrays have identified over 4,000 genes whose expression is influenced by GHK-Cu, with effects spanning multiple functional categories including tissue remodeling, antioxidant defense, and growth factor signaling

An important challenge for future studies will be to define which nodes within this multilayered GSH-centered defense network represent true therapeutic vulnerabilities across different tissue and tumor contexts