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Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

[DOI] [PubMed] [Google Scholar] 84.Giustarini D., Galvagni F., Dalle Donne I., Milzani A., Severi F.M., Santucci A., Rossi R

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1,4-benzenediol (493 mg, 4.56 mmol) was dissolved in a mixture of water (50 mL) and 60% perchloric acid (3.6 mL)