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Months 36: more robust weight loss, better HbA1c control, improved lipid and blood pressure markers

Symptomatic management for mild injection site reactions includes: Applying a cool compress or ice pack wrapped in a thin cloth for 10 to 15 minutes to reduce swelling and discomfort Avoiding rubbing or massaging the injection site, which may increase irritation Using over-the-counter oral antihistamines (such as cetirizine or loratadine) for itching, if approved by a healthcare provider Applying fragrance-free, hypoallergenic moisturizer to dry or irritated skin around (not directly on) the injection site Patients should consult their healthcare provider before applying topical medications to injection sites, as these may mask signs of infection

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An arginine substitution at position 34 prevents binding in the wrong location

This is one reason semaglutide tends to produce the most dramatic early results in people with higher starting weights