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Nevertheless, achieving therapeutic efficacy with AAV often requires high viral titers, raising potential issues of dose-dependent cytotoxicity, immune responses, and eventual transgene silencing (179)

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Unapproved products are risky not only because they havent been reviewed by the FDA, but because theres no way to know their potency, possible contamination, or potential dosing errors

Role in Insulin Sensitivity Research suggests that glutathione may help improve insulin sensitivity