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g , qPCR analysis of indicated genes in gWAT from Control, Bmal1 -KO, and Bmal1 -KO + NDI1 mice (Control n = 12, Bmal1 -KO n = 12, Bmal1 -KO + NDI1 n = 7)

peptide analogues of GLP-1 have therefore been developed and successfully used clinically for the treatment of T2D and obesity, including exendin-4, liraglutide, and semaglutide, amongst others (1, 2, 5)

Melanotan II is discussed online as a melanocortin-pathway peptide associated with increased pigmentation signaling, but responses can vary widely and side effects are commonly reported