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Excessive iron can induce mitochondrial dysfunction in chondrocytes by producing reactive oxygen species (ROS), thereby promoting the expression of OA catabolic markers ( 3.2 Synovial inflammation and ferroptosis Synovial inflammation is another critical feature in the pathological progression of OA and may even precede cartilage degeneration (Scanzello and Goldring, 2012)

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Drugs Exp Clin Res 1992;18:355-65