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These FFAs activate NFB among others, and lead to lipotoxicity, which can result in lipid accumulation in the liver [190, 215]

[DOI] [PubMed] [Google Scholar] 81.Taggart M.W., Abraham S.C., Overman M.J., Mansfield P.F., Rashid A

Picard, D

Key Takeaways Glutathione is an essential molecule since it has an important role in detoxification processes and immune function

Targeting these amino acid-driven metabolic circuits may offer novel therapeutic opportunities in fibrotic diseases such as IPF, where metabolic vulnerabilities can be exploited to disrupt fibroblast activation and excessive ECM remodeling