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IV zinc differs in several ways: Delivered directly into circulation Avoids gastrointestinal irritation Allows for predictable absorption Can be combined with hydration and other supportive nutrients IV administration may be considered when oral intake is insufficient, poorly tolerated, or ineffective in meeting short-term physiological demand

Hypokalemia and thrombocytosis can occur upon conversion of severe megaloblastic anemia to normal erythropoiesis with vitamin B12 therapy

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One study found that even up to 2,000 micrograms a day of methylcobalamin wasnt enough to correct vitamin B12 deficiency in one of three vegans tested

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