Mistake 5: putting tirzepatide back in the fridge after room temperature storage For brand-name pens, once removed from refrigeration, the 21-day room temperature clock starts
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There is no clinical evidence suggesting that nighttime administration reduces efficacy or increases adverse effects compared to morning or afternoon dosing
The honest summary: strong mechanistic and animal evidence, essentially no completed human efficacy trials
Methods: A systematic search was conducted in three electronic databases, namely Embase, PubMed, and the Cochrane Library, up until March 1, 2023, to identify randomized controlled trials (RCTs) comparing tirzepatide to either placebo or active hypoglycemic drugs in individuals with T2D and obesity
