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222 The major function of the endoplasmic reticulum (ER) is the synthesis and folding of secreted and transmembrane proteins, increasing evidence suggests that persistent ER stress is associated with the onset and progress of chronic metabolic disorders like obesity and IR

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Interestingly, this hypothesis is also supported by the finding of significant hypocholesterolemia in up to 20% of children with isolated ASD (73)

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Other skin care products and other topical or systemic acne medications were prohibited throughout the study period