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3.1.3 DON DON (6-diazo-5-oxo-l-norleucine), a glutamine analog, irreversibly inhibits various glutamine utilization enzymes, such as glutaminase and glutamine synthetase, by forming covalent bonds with nucleophilic residues on the active site of the enzyme (Rajagopalan and DeBerardinis, 2011

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Ali N., Sohail R., Jaffer S.R., Siddique S., Kaya B., Atowoju I., Imran A., Wright W., Pamulapati S., Choudhry F., et al

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By aiding in cellular metabolism, glutathione may help increase energy, reduce fatigue, and improve overall cognitive function

Endocr Metab Immune Disord Drug Targets 23(1):8694