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157 FMRP is an RNA-binding protein whose target mRNAs encode transcription factors, and chromatin modifiers have been identified by high-throughput sequencing of RNA isolated with cross-linking immunoprecipitation (HITS-CLIP)

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While the FDA prescribing information does not list hepatotoxicity as a recognized adverse effect, understanding the medication's safety profileincluding rare case reports and labeled risks like gallbladder diseasehelps patients and providers make informed treatment decisions

There are also supplements that provide energy substrates that can refill deficient C4 carbon TCA cycle intermediates (anaplerosis), which thereby will improve oxidative phosphorylation of any fuel in addition to providing alternative fuel