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Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress

The risk may increase with rapid weight loss - more than 3.3 pounds per week - as this can lead to gallstones that might trigger pancreatitis

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Serious Adverse Events Serious adverse events are uncommon but include acute pancreatitis (incidence similar to other GLP-1 agonists, approximately 0.2%), gallbladder disorders (cholecystitis, cholelithiasis) occurring more frequently than placebo likely due to rapid weight loss, and rare cases of severe hypoglycemia when combined with insulin or sulfonylureas

Abnormal HPA axis signaling can cause persistent cortisol increase, causing oxidative stress via many mechanisms, including mitochondrial dysfunction and endoplasmic reticulum stress (54)