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Diabetes, Obesity and Nutrition Working Group of the Spanish Society of Internal Medicine (SEMI)

Managing Energy Successfully on Semaglutide Fatigue on semaglutide is real but usually manageable and temporary

In the present study, significant reductions in testosterone, LH, LH/FSH ratio, fasting insulin, and HOMA-IR were observed in the semaglutide-intensified treatment group compared to baseline measurements after 12 weeks of semaglutide treatment

More practically relevant: tell any clinician treating you, including before planned surgery, that you take it, since slowed stomach emptying matters for anaesthesia and fasting instructions, and the effect persists for weeks after a last dose

Long-Term Side Effects and Considerations Most discussion focuses on initial side effects, but what about long-term use