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Wu, J., Liu, S., Meng, H., Qu, T., Fu, S., Wang, Z., Yang, J., Jin, D., & Yu, B

When prescribed in the usual oral dosage range of 250 to ~2550 mg/day for the treatment of T2DM and in the absence of reduced renal function, it is unlikely that peak plasma levels of metformin would exceed 15-20 M, with trough levels of between 1-5 M, and a plasma half-life of approximately 3 to 5 hours

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