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Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class

Jardiance belongs to a drug class called SGLT2 (sodium-glucose cotransporter) inhibitors

The results of HE staining showed that compared with the control group, the model group had swollen hepatocytes and vacuolar changes (mainly steatosis)

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