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Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

Interestingly, the elevated CHAC1 levels in TP53-mutant cells might represent an adaptive response, potentially compensating for defective ferroptosis pathways or preventing harmful GSH accumulation

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While numerous clinical studies in humans have assessed curcumins systemic effects following oral intake, none have evaluated its tissue distribution