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In this regard it was recently observed that genomic features that affect the accessibility of a specific chromosome region to recombination, including GC content and CpG fraction, are altered in at least a proportion of oocytes with MI and MII errors, and particularly in those with recombinant events occurring in proximal regions, suggesting that factors characteristic of peri-centromeric DNA such as chromatin structure or epigenetic modifications may affect the accessibility of a specific chromosome region to recombination in at least a proportion of oocytes with meiotic errors (Oliver et al., 2014)

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