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Combine shipping time with any additional room-temperature exposure during your use period, and you could exceed that 28-day window faster than you realize

If needed, Wegovy can be stored in the original carton at 46 F to 86 F (8 C to 30 C) for up to 28 days before removing the pen cap

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10 It also inactivates GLP-1 (and the other human incretin GIP) rapidly and thus activity of GLP-1 in non-augmented physiology is relatively short lived ( 70% had existing cardiovascular disease (CVD) (EXSCEL)

Combining lifestyle changes with supplements often delivers the best results