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After 2 weeks, you can reduce this to weekly injections for 1 to 2 months and then to monthly injections

A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss

Conversely, if you are a vegetarian or vegan, you might need to rely more on B12 shots or supplements to maintain adequate B12 levels

Here's how the most common options compare

This conversion process can be less efficient in individuals with certain genetic mutations or metabolic issues, making Methylcobalamin a more effective option for these populations