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2 Among these, cold exposure and fasting are well-studied paradigms that necessitate metabolic flexibility, prioritizing fatty acid oxidation over glucose catabolism to sustain systemic energy balance while sparing glucose for obligate tissues such as the brain

As indicated by the below graphs, the majority of participants unknowingly had suboptimal levels, but are still considered healthy by conventional standards

Veys KR, DHauwers KW, van Dongen A, Janssen MC, Besouw MTP, Goossens E, van den Heuvel LP, Wetzels A, Levtchenko EN (2018) First successful conception induced by a male cystinosis patient

Disease states of GH excess (e.g., acromegaly) and GH deficiency (e.g., congenital isolated GH deficiency) are characterized by increased and decreased GH, IGF-I and insulin levels, respectively, where the GH/IGF-I relationship is reflected by a primary association