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Some medications can also affect absorption of Vitamin B12 in the gut, and B12 deficiency can be an issue if you have had weight loss surgery

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Because this formulation provides multiple B vitamins at significant doses, it is important to consider how each component might interact with medications or other supplements the patient is taking

Underlying conditions: digestive disorders like Crohn's or celiac disease, or autoimmune conditions, can cause you to use up B12 faster and may call for more frequent injections