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Funding Open access funding provided by Deutsches Krebsforschungszentrum (DKFZ)

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Protein crystals for Gpa-GSS30 were obtained in JCSG E1 (0.2 M magnesium formate di-hydrate and 20% PEG 3350) and the structure solved/refined/validated as described above, using Gpa-GS22-apo for molecular replacement

By exploring the limitations of consensus-based guidelines and the need for more robust primary research, this discussion aims to inform future clinical decisions, improve patient safety, and advocate for updated protocols that balance efficacy with the complexities of modern pharmacotherapy