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The average diet supplies about 5 to 15 mcg/day of vitamin B 12in a protein-bound form that is available for absorption after normal digestion
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In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]
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