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Potential direct hepatic effects have also been identified in preclinical studies, though GLP-1 receptors are expressed at relatively low levels in the liver itself

ASA consensus-based guidance of preoperative management of patients on GLP-1, published in June 2023, recommends that patients on daily dosing consider holding GLP-1 agonists on the day of the procedure

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This study identifies a causal relationship between five circulating metabolites and myocarditis

It has also been suggested that a common functional genetic polymorphism in the gene may contribute to the etiology of alcoholism (Wang et al., 2001)