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It may occur through mechanisms including hypoglycaemia (especially when combined with insulin or sulphonylureas), dehydration from gastrointestinal side effects, orthostatic hypotension, or reduced caloric intake

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Conclusions In addition to the conventional mechanism of desensitization, which occurs on the plasma membrane and in the cytosol, this study provides a new insight that another desensitization pathway in which nuclear trafficking plays a critical role is operating

Factors that increase the risk of acetaminophen-induced hepatotoxicity (explained above )

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