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Adults with type 2 diabetes were eligible for the industry-sponsored FLOW (Evaluate Renal Function with Semaglutide Once Weekly) trial if they had high-risk kidney disease and were receiving a stable maximal dose of renin-angiotensin system (RAS) inhibitors

Clinical evidence: what the STEP trials show Numbers matter

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ABSTRACT Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated considerable efficacy in the treatment of diabetes and obesity, it is essential to recognize that their use is associated with certain intrinsic risks that must not be disregarded

More noticeable weight changes might occur only after higher doses are reached and tolerated