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-TrCP is a substrate receptor of the Skp1-Cul1-Rbx1/Roc1 ubiquitin ligase complex and therefore targets Nrf2 for ubiquitination and proteasomal degradation

Thirdly, these results need to be interpreted with caution due to the potential differences in T1 and T2 relaxation times between different individuals and groups and their effects on neurochemical concentrations