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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

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For morphometric analysis of granuloma and immune cell infiltration, the H&E stained mice lung sections were analyzed using Path Scan Enabler-5 (Mayer Scientific, TX, United States) followed by morphometric determination of the area of lung involved in granulomatous response using Sigma Scan Pro (Systat Software Inc., CA, United States) as described previously ( Quantification of Glutathione Levels GSH levels were measured in the lung lysates of untreated, 40 mM L-GSH, RIF, and RIF +40 mM GSH treated diabetic mice at 4-weeks and 8-weeks post-infection

TB-500 Loading: 1,250 mcg twice weekly for 4 weeks (total ~2.5 mg/week)