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PHD activates the pseudohypoxic response by stabilizing HIF-1, which is a well-known tumorigenesis enhancer, and as a transcription factor, maintains the metabolic reprogramming of cancer cells to support their survival 127

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The aim was to judge whether plasma B12 concentrations (mostly representing vitamin B12 bound to TCN1) were proportionally higher than B12 levels bound to transcobalamin in the patients, versus the controls