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On the basis of theoretical considerations, it was hypothesized that the operon encodes for a malic semialdehyde dehydrogenase (MSA-DH) which enables for the subsequent conversion of MSA into L-malate which might be channelled into the tricarboxylic acid cycle (Zhu et al., 2014)

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PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma

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To evaluate the incidence of MACE-4 events in patients treated with tirzepatide compared to the control group, a meta-analysis was conducted using data from 7778 patients enrolled in the SURPASS-4 study, SURPASS Clinical Trails Program (which includes 7 randomized clinical trials), and SURMOUNT-1