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The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

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To better assess the effectiveness of the two index drug classes, we used a new user design and excluded individuals using the direct comparison drug or any kind of GLP-1 RA at baseline

Angiogenesis plays a pivotal role by enhancing the delivery of oxygen and nutrients to granulation tissue at the injury site, thereby accelerating the reparative response [12]