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In COPD, Th17 cell numbers are increased, and their activity correlates with disease severity (102)
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Although the MT1 and MT2 receptors feature fairly conserved binding pockets for melatonin, they also take distinctive conformational states that modulate ligand selectivity, important for designing subtype-specific therapeutics [39]
References Abdel-Gaber SA, Mohammed RK, Refaie MMM (2018) Mechanism mediating the protective effect of diacerein in ischemia-reperfusion-induced testicular injury in rats
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