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Author contributions WZ, JC, and HX designed and wrote the paper

If you're on Wegovy, Zepbound, or another GLP-1 medication, this experience probably sounds familiar

You can develop skin cancer on the inner thigh, outer thigh, knee, knee cap, shin, calf, or even the back of the leg, or any other part of the leg that has been exposed to ultraviolet radiation

Endoxifen, the most potent metabolite is produced via N - demethylation of tamoxifen to form N -desmethyltamoxifen (NDM) whereas CYP2D6 catalyzed 4-hydroxylation of NDM to form endoxifen

Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors